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Unconjugated Rabbit anti-Human, Mouse, Rat RNF40 (8D8) Monoclonal Antibody [IgG]
Výrobce: Bioss Katalogové č.: bsm-54467R Aplikace: Western Blot, Imunohistochemie, Imunoprecipitace, imunoaglutinace Reaktivita: Human, Mouse, Rat Původ: Rabbit Klonalita: Monoclonal Podtřída: IgG Status: RUO Dodatečné informace: Produkt na webu výrobce Popis:E3 ubiquitin-protein ligase BRE1B; BRE1-B; 95 kDa retinoblastoma-associated protein; RBP95; RING finger protein 40; RING-type E3 ubiquitin transferase BRE1B; KIAA0661
Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.