TRAF6 Polyclonal Antibody, Biotin Conjugated

AI851288; 2310003F17Rik; C630032O20Rik; TNF receptor-associated factor 6; E3 ubiquitin-protein ligase TRAF6; Traf6

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys63'linkedpolyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (By similarity). Leads to the activation of NFkappaB and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses cMybmediated transactivation, in Blymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL1 receptor and IL17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP1) and NFkappaB, in response to RANKL stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in Bcells and macrophages, and thus may play a role in the regulation of immunoglobulin production.