TLR4 Polyclonal Antibody

Lps; Ly87; Ran/M1; Rasl2-8; Toll-like receptor 4; CD284; Tlr4

Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NFkappaB activation, cytokine secretion and the inflammatory response. Also involved in LPSindependent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized lowdensity lipoprotein (oxLDL) or amyloidbeta 42. In this context, the initial signal is provided by oxLDL or amyloidbeta 42binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NFkappaBdependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.