ALEXA FLUOR 488 Rabbit anti-Human, Mouse, Rat, Rabbit TGF Beta 1+2+3 Polyclonal Antibody, ALEXA FLUOR 488 Conjugated [IgG]
Výrobce: Bioss Katalogové č.: bs-4538R-A488 Aplikace: Imunofluorescence Reaktivita: Human, Mouse, Rat, Rabbit Původ: Rabbit Klonalita: Polyclonal Konjugát: AlexaFluor488 Laser: 488 nm (modrý) Podtřída: IgG Status: RUO Dodatečné informace: Produkt na webu výrobce Popis:CED; LAP; DPD1; TGFB; TGFbeta; Transforming growth factor beta-1; TGF-beta-1; TGFB1; TGFB2; TGFB3
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells.