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Cy5.5 Rabbit anti-Human, Rat Rb/p105-Rb(Ser780) Polyclonal Antibody, Cy5.5 Conjugated [IgG]
Výrobce: Bioss Katalogové č.: bs-1347R-Cy5.5 Aplikace: Imunofluorescence, Průtoková cytometrie Reaktivita: Human, Rat Původ: Rabbit Klonalita: Polyclonal Konjugát: Cy5 Laser: 633 nm (červený) Podtřída: IgG Status: RUO Dodatečné informace: Produkt na webu výrobce Popis:RbSer780; OSRC; P105 RB; P105RB; PP105; PP110; pRb; RB 1; RB1; RB1 protein; Retinoblastoma 1 including osteosarcoma; Retinoblastoma 1; Retinoblastoma associated protein; Including osteosarcoma; Osteosarcoma; p105-Rb; Rb; RB_HUMAN; Retinoblastoma suspectibility protein; Retinoblastoma-associated protein; Retinoblastoma related osteosarcoma; Retinoblastoma susceptibility gene.
Nuclear Marker.The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.