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ALEXA FLUOR 555 Rabbit anti- MSH3 Polyclonal Antibody, ALEXA FLUOR 555 Conjugated [IgG]
Výrobce: Bioss Katalogové č.: bs-8542R-A555 Aplikace: Imunofluorescence Reaktivita: Ostatní Původ: Rabbit Klonalita: Polyclonal Konjugát: Alexa Fluor 555 Laser: 550 nm (zeleno-žlutý) Podtřída: IgG Status: RUO Dodatečné informace: Produkt na webu výrobce Popis:Divergent upstream protein; DNA mismatch repair protein; DNA mismatch repair protein Msh 3; DNA mismatch repair protein Msh3; DUC 1; DUC1; DUG; DUP; hMSH3; Mismatch repair protein 1; MRP 1; MRP1; MSH 3; MSH-3; MSH3_HUMAN; MutS homolog 3.
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.