HRP Rabbit anti- Lck (Tyr505) Polyclonal Antibody, HRP Conjugated [IgG]

LCK phospho Y505; LCK phospho Tyr505; p-LCK Tyr505; p56-LCK; Lymphocyte cell-specic protein-tyrosine kinase; LSK; T cell-specic protein-tyrosine kinase; Lck p56; LSK; Lymphocyte Specic Protein Tyrosine Kinase; Membrane associated protein tyrosine kinase; Oncogene lck; P56 LCK; p56LSTRA protein tyrosine kinase; p56lck; pp58 lck; pp58lck; Proto oncogene tyrosine protein kinase LCK; Protooncogene tyrosine protein kinase LCK; T cell specic protein tyrosine kinase; T lymphocyte specic protein tyrosine kinase p56lck; YT 16; YT16; LCK_HUMAN.

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008].