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ALEXA FLUOR 647 Rabbit anti-Human, Mouse IL1 Receptor I Polyclonal Antibody, ALEXA FLUOR 647 Conjugated [IgG]
Výrobce: Bioss Katalogové č.: bs-2594R-A647 Aplikace: Průtoková cytometrie Reaktivita: Human, Mouse Původ: Rabbit Klonalita: Polyclonal Konjugát: AlexaFluor647 Laser: 633 nm (červený) Podtřída: IgG Status: RUO Dodatečné informace: Produkt na webu výrobce Popis:P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha; Interleukin-1 receptor type 1; IL-1R-1; IL-1RT-1; IL-1RT1; CD121 antigen-like family member A; Interleukin-1 receptor alpha; Interleukin-1 receptor type I; IL1R1; IL1RT1
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.