Cy7 Rabbit anti-Human, Mouse, Rat Caspase 3 Polyclonal Antibody, Cy7 Conjugated [IgG]

Lice; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; IRP; Protein Yama; SREBP cleavage activity 1; SCA-1; Casp3; Cpp32

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity).