Pro-Collagen 1 Polyclonal Antibody

Collagen alpha-1(I) chain; Alpha-1 type I collagen; COL1A1, Pro-collagen 1.

This gene encodes the proalpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibrilforming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types IIV, EhlersDanlos syndrome type VIIA, EhlersDanlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for plateletderived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. Type I collagen levels have been linked to bone growth and formation. Levels of the Cterminal propeptide are indicative of collagen production in vivo. Elevated levels of Cterminal propeptide have been shown in diseases associated with high levels of bone turnover, including Pagets disease, hyperthyroidism, primary hyperparathyroidism and renal osteodystrophy. Slightly elevated levels of Cterminal propeptide have also been documented in some women in early menopause.