Unconjugated Mouse anti-Human TFRC (4C1) Monoclonal Antibody [IgM]

Výrobce: Bioss Katalogové č.: bsm-51161M Aplikace: Western Blot Reaktivita: Human Původ: Mouse Klonalita: Monoclonal Podtřída: IgM Status: RUO Dodatečné informace: Produkt na webu výrobce Popis:

T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46; Transferrin receptor protein 1; TFRC

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.

100ul
13 610 Kč
bez DPH
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