Unconjugated Mouse anti-Human PRKAA2 (6C2) Monoclonal Antibody [IgG2a]

AMPK; AMPK2; PRKAA; AMPKa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; PRKAA2

The protein encoded by this gene is a catalytic subunit of_x000D_ the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer_x000D_ consisting of an alpha catalytic subunit, and non-catalytic beta_x000D_ and gamma subunits. AMPK is an important energy-sensing enzyme that_x000D_ monitors cellular energy status. In response to cellular metabolic_x000D_ stresses, AMPK is activated, and thus phosphorylates and_x000D_ inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy_x000D_ beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in_x000D_ regulating de novo biosynthesis of fatty acid and cholesterol._x000D_ Studies of the mouse counterpart suggest that this catalytic_x000D_ subunit may control whole-body insulin sensitivity and is necessary_x000D_ for maintaining myocardial energy homeostasis during ischemia.