Unconjugated Mouse anti-Human CDH1 (9C8) Monoclonal Antibody [IgG1]

UVO; CDHE; ECAD; LCAM; Arc-1; CD324; Cadherin-1; CAM 120/80; Epithelial cadherin; E-cadherin; Uvomorulin; CDH1

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.