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CASP8 Polyclonal Antibody, Biotin Conjugated
Výrobce: Bioss Katalogové č.: bs-0052R-Biotin Aplikace: Western Blot, Imunohistochemie, ELISA, ELISPOT Reaktivita: Human, Mouse, Rat, Monkey, Sheep Původ: Rabbit Klonalita: Polyclonal Konjugát: Biotin/Purifikovaná Laser: Ostatní Podtřída: IgG Status: RUO Dodatečné informace: Produkt na webu výrobce Popis:MACH; Mch5; FLICE; CASP-8; Caspase-8; Casp8
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called deathinducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the Nterminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP1. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the smallmolecule substrate, AcAspGluValAsp|AMC. Likely target for the cowpox virus CRMA death inhibitory protein.