protilatky.sk
AKT1/2/3 (Ser472/Ser473/Ser474) Antibody
Výrobce: Bioss Katalogové č.: bs-0876R Aplikace: Western Blot, Imunofluorescence, Imunohistochemie, ELISA, ELISPOT Reaktivita: Human, Mouse, Rat, Rabbit, Chicken, Fish, Bovine Původ: Rabbit Klonalita: Polyclonal Podtřída: IgG Status: RUO Dodatečné informace: Produkt na webu výrobce Popis:Akt; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; RAC-PK-alpha; Akt1
AKT1specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.