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HRP Mouse anti-Human, Mouse, Rat Active Caspase 3 Monoclonal Antibody, HRP Conjugated [IgG]
Výrobce: Bioss Katalogové č.: bsm-33199M-HRP Aplikace: Western Blot, Imunohistochemie Reaktivita: Human, Mouse, Rat Původ: Mouse Klonalita: Monoclonal Konjugát: HRP Laser: Ostatní Podtřída: IgG Status: RUO Dodatečné informace: Produkt na webu výrobce Popis:Caspase-3 subunit p17; APOPAIN; CASP3; Caspase 3 apoptosis related cysteine protease; Caspase3; CPP32; CPP32B; Cysteine protease CPP32; Human cysteine protease CPP32 isoform alpha mRNA complete cds; PARP cleavage protease; SCA 1; SCA1; SREBP cleavage activity 1; Yama; CASP3_HUMAN; Caspase-3; CASP-3; Apopain; Protein Yama; SREBP cleavage activity 1; SCA-1.
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.